![]() To reduce bias from conditions unrelated to MacTel, 27 only microperimetric data from test points within the central 10° of the MP1 grid were considered in calculations. En face SD-OCT images and microperimetric retinal sensitivity threshold data were superimposed over images of the fundus and adjusted to attain exact correspondence. Written, informed consent was obtained from each participant after explanation of the nature of the study.Īn approximate calibration of distances within the en face OCT image to metric units was performed based on the uniform 6-mm width of the scan raster. The study protocol adhered to the tenets of the Declaration of Helsinki and was approved by the local institutional ethics committee. Treated eyes and eyes containing dense pigment plaques obscuring the deeper layers of the retina or showing signs of neovascularization at baseline were excluded. 27 Eyes of participants from one site within the study with at least 1 year of follow-up and available SD-OCT volume scans, demonstrating a break in the IS/OS line at baseline were included. Patients were selected from the cohort of the MacTel project, an international multicenter prospective natural history study of type 2 MacTel, currently involving 27 research centers worldwide. Mean follow-up time was 1.9 years (SD = 0.6 years range: 1–3 years). Thirty-nine eyes of 23 patients, ranging in age at baseline from 46 to 76 years (mean = 62.3 years, SD = 9.2 years 11 males, 12 females), were examined. En face OCT imaging of the IS/OS layer provides a functionally relevant method for documenting disease progression in type 2 MacTel. The mean annual rate of change in aggregate sensitivity loss was 5.14 dB (SE = 1.51, 95% CI: 2.19–8.10 dB, P < 0.001, n = 37), a significant correlation with lesion area increase was found ( P = 0.006).īoth IS/OS break area and rate of enlargement correlate with aggregate retinal sensitivity loss in type 2 MacTel. Mean aggregate retinal sensitivity loss was at baseline 28.56 dB (SE = 5.43, 95% CI: 17.32–39.80 dB, n = 28), a positive correlation with IS/OS lesion area was present ( P < 0.001). The cluster-adjusted mean annual progression rate in IS/OS break area was 0.140 mm 2 (SE = 0.040, 95% CI: 0.062–0.218 mm 2, P < 0.001). Mean follow-up time was 1.9 years (range: 1–3 years). Thirty-nine eyes of 23 patients (mean age: 62.3 ± 9.2 years) were analyzed. Changes over time in an area of IS/OS defects and retinal sensitivity were analyzed. Aggregate retinal sensitivity loss within IS/OS lesions was calculated. Retinal sensitivity thresholds were determined using a retinal microperimeter unit. En face images were created by manual segmentation of the IS/OS junctional line in volume scans acquired using a spatial-domain optical coherence tomography retinal imaging unit. Patients with at least 1 year of follow-up were selected from the MacTel Study. To document the progression of a break in the photoreceptor inner segment/outer segment (IS/OS) junction layer and its functional correlates over time in the natural history of type 2 idiopathic macular telangiectasia (type 2 MacTel).
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